Description
Product Characteristics:
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.
Subcellular location: Cell membrane
Synonyms: Adapter protein, FLJ33531, IL 1RAcPIP, IL1RAcPIP, TOLIP, TOLIP_HUMAN, Toll interacting protein, Toll-interacting protein, tollip.
Target Information: This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]